Edge Genomics

Life Science

Research Technologies

We introduce reliable, safe and effective solutions by using human genome next-generation sequencing technologies to enable precision medicine for individuals and healthcare professionals, in the diagnosis and therapy of chronic/rare diseases and cancer, providing the highest level of flexibility and customization according to their needs.

Mutations

Genomics

Hereditary

Tumor

Newborn

Carriers

Genes & Panels

Sequencing

About

By harnessing the power of genomics and applied biotechnology, we make medical genetics flexible, affordable and accessible to deliver diagnostic and precision medicine that improves the everyday lives of those around us. All of this is done by working side-by-side with every one of our clients, driven by meaningful relationships, passion, and purpose.

 

Our team of medical experts has developed reliable, comprehensive and actionable genetic tests, using next-generation sequencing of the genome and individual cells by using any of our 18000+ genes.

 

Currently, we are developing next-generation medicines for people suffering from cancer, chronic and rare diseases worldwide. We change the genetic expression by editing certain DNA sequences by applying CRISPR-Cas technologies.

The most advanced sequencing capability in the world.

Diploide is a leading provider of genomic services and solutions with next-generation NGS with the most extensive experience in bioinformatics, and the most advanced sequencing capability in the world.

 

We offer a wide range of next-generation sequencing services with the world's largest portfolio of genetic testing panels, enhanced with the ability to develop algorithms, chips, specific and / or specialized arrangements for medical institutions, research institutions and other partners. Public and private.

CRISPR-Cas

We are developing CRISPR platforms that use gene editing; A revolutionary approach to drug development. Advances in this technology have allowed us to modify almost any gene in human cells, which means that we will soon be able to treat a wider range of diseases.

 

CRISPR (pronounced "crispier") is an acronym for "Clustered, regularly spaced, short palindromic repeats" and refers to a newly developed gene editing technology, which can review, eliminate and replace DNA in a highly precise manner. CRISPR is a dynamic and versatile tool that allows us to access and edit almost any sequence in the genome and has the potential to help us develop medications for people with a wide variety of diseases. We see CRISPR as a "platform" technology with the ability to edit DNA in any cell or tissue.

AI applied to health sciences

We synthesize biomedical knowledge and experience in biomarkers to guide their strategic planning. Artificial intelligence allows researchers to establish an effective differentiation or combination of biomarkers, to recruit the right patients and identify the best complementary diagnostic and therapeutic opportunities.

CAP / CLIA certified laboratories

DNA sequencing is performed in laboratories in the US, Canada, Asia and Europe, which are certified to meet CAP and CLIA standards.

 

A laboratory certified by CAP and CLIA must meet certain quality standards, including qualifications for people performing genetic tests and other standards that guarantee the accuracy and reliability of the results.

Technology

Pipeline

DNA sequencing is performed in laboratories in the US, Canada, Asia and Europe, which are certified to meet CAP and CLIA standards.

 

A laboratory certified by CAP and CLIA must meet certain quality standards, including qualifications for people performing genetic tests and other standards that guarantee the accuracy and reliability of the results.

NUTRIGENOMICS
MOLECULAR GENETICS
PHARMA
SEQUENCING
NGS
SINGLE CELL
SEQUENCING
CRISPR-CAS

Pipeline

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Benefits

Ntrigenomics

Proactive Health

For optimal health, the body needs the proper balance of nutrients, environment and lifestyle to function properly. This means that incorrect habits and food choices can contribute to symptoms, which are often the first warning signs of developing health problems.

 

Our nutrigenomic panels reveal how genes impact weight loss and body composition, nutrient metabolism, heart health, performance, fertility, food intolerances, eating habits, risk of injury, propensity to chronic degenerative diseases and skin health among many other genetic aspects.

 

Diploide Genetics is also committed to supporting scientific research to strengthen our understanding of the role of nutrition in human health alongside Mayo Clinic, Cleveland Clinic, Andresen Center, University of Toronto, Berkeley University, UCLA and Broad Institute.

Next Generation Sequencing

Clinical Grade

Next generation sequencing (NGS), allows a better understanding of genetic diseases and has become a significant technological advance in the practice of diagnostic and clinical medicine. NGS allows the analysis of multiple regions of the genome in a single reaction and has been shown to be a cost effective and efficient tool in the investigation of patients with genetic diseases.

Molecular Genetics

NGS technology has high speed and performance, both quantitative and qualitative sequence data, equivalent to human genome project data, in 10-20 days. Numerous different methods are used in which NGS is being applied to identify the causative genetic variant in rare diseases. Complete exome sequencing (WES), complete genome sequencing (WGS), methyloma sequence, transcriptome sequence and other forms of sequencing are used in NGS methods.

 

There is a growing number of reports that identify the causal variants of the diseases. More than 100 causative genes have been identified in various Mendelian diseases by the exome sequencing method. In addition to the discovery of disease genes that are dominant and recessive, WES has been applied to determine somatic mutations in tumors and rare mutations with moderate effect on common disorders, as well as clinical diagnoses.

Cancer

By harnessing the power of genomics and applied biotechnology, we make medical genetics affordable and accessible to all, to apply diagnostic and precision medicine to billions of people.

 

Our team of medical experts has developed reliable, comprehensive and actionable genetic tests, using next-generation sequencing of the genome and individual cells.

 

Currently, we are developing next-generation medicines for people suffering from cancer, chronic and rare diseases worldwide. We change the genetic expression by editing certain DNA sequences by applying CRISPR-Cas technologies.

Single Cell Sequencing

Single Cell Gene Expression

Advances in the coming decades will transform the world. We accelerate this progress by driving fundamental research in life sciences, including oncology, immunology and neuroscience.

 

We go beyond the traditional analysis of gene expression to characterize cell populations, cell types, cell states and more, cell by cell. From the evaluation of tumor heterogeneity and the composition of stem cells, to the dissection of neuronal populations: the technological advances provided by the gene expression solution of individual chromium cells, together with turnkey software tools, allow the creation of High complexity libraries from individual cells to maximize knowledge of any type of sample.

Single Cell Immune Profiling

With our simplified workflows, you can move from sample preparation to library, immune sequencing and software analysis, revealing information about the diversity of T and B cells, V (D) J recombination and the profile of immune cells From research in immunology and immuno-oncology to the investigation of infectious diseases and more, these solutions will accelerate the understanding of the adaptive immune system.

Assay for Transposase Accessible Chromatin

The ATAC Single Cell solution also includes intuitive software analysis and visualization tools for a refined analysis of gene regulatory networks in individual cells. The single-cell chromium ATAC solution can be used to study developmental plasticity, cellular heterogeneity and more.

CRISPR-Cas

Gene Silencing

Cas9 endonuclease has become a popular tool for targeted gene editing in eukaryotic systems [1-3]. With the use of a target-specific CRISPR RNA (cRNA) and a transactivating cRNA (tracrRNA), or a fused format called single guide RNA (gRNA), the Cas9 endonuclease can attack locations within complex mammalian genomes to obtain a double rest stranded. These ruptures can be repaired by endogenous DNA repair mechanisms through a process collectively known as non-homologous final binding (NHEJ). Because the NHEJ is prone to errors, genomic (indel) deletions or insertions can occur that create framework changes and premature termination to permanently silence the target genes.

DNA-free CRISPR-Cas9 Gene Editing

What does the CRISPR-Cas9 gene edition "without DNA" really mean? It means that your system does not use CRISPR-Cas9 components in the form of DNA vectors; Each component is RNA or protein. Starting with Cas9 mRNA or purified Cas9 protein as a source of expression of Cas9 nuclease in genome engineering experiments has advantages for some applications. Why? The use of DNA-based Cas9 or guide RNA expression systems entails the possibility of undesirable genetic alterations due to the integration of plasmid DNA at the cut-off site or integrations of random lentiviral vectors. For this reason, a gene editing system without DNA can be a good option to create designed cell lines.

Homology-directed repair (HDR)

CRISPR-Cas9 induced double chain disruption can also be used as an opportunity to create a knockin, rather than a knockout of the target gene. The precise insertion of a donor template can alter the coding region of a gene to "fix" a mutation, introduce a protein tag or create a new restriction site. We have shown that single-stranded DNA can be used to create precise insertions using synthetic crRNA and tracrRNA with Cas9 nuclease. Alternatively, the activity of Cas9 can be altered to dent instead of performing a double-stranded cut. Casase Nickase can be used with a pair of RNAcr complexes: tracrRNA or sgRNA targeting two closely spaced regions on opposite strands, and when used with a short double stranded DNA, homology directed repair can be performed.

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